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Results: We show that the peripherally restricted CB1 agonist (4-morpholine 0.3, 0.6, and 1 mg/kg) does not induce respiratory depression, while our previous studies showed that a central penetrating synthetic cannabinoid does induce respiratory depression. Jayaraman Selvakumar,a Alexandros Makriyannisb and Chinnasamy Ramaraj Ramanathana. In this study we sought to define the roles of central versus peripheral CB1R activation on respiratory depression alone and in combination with morphine using whole body plethysmography.
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Methods: With recent evidence of cannabinoid receptor 1 (CB1R) presence in the collection of respiratory neurons in the brainstem, as well as in the peripheral lung tissue, it is vital that the mechanisms involved in central and peripheral CB1R modulation of respiratory function be delineated. Buy Drug Discovery Strategies and Methods by Alexandros Makriyannis, Diane Biegel from Waterstones today Click and Collect from your local Waterstones or. the Medicinal Chemistry Reviews as PDF, an outstanding 600 page. Regular membership is 25 per year (students 10), and it includes. If you are not an ACS member, you may not vote in MEDI elections, but you will still receive other member benefits. Professor of Pharmaceutical Science, Chemistry and Chemical Biology. Wether or not you are a member of the American Chemical Society, you can join the MEDI Division. Introduction: Cannabis acceptance and use continues to rise despite the gaps in knowledge regarding the mechanisms of cannabinoids and the endocannabinoid system in many physiological functions, including respiratory influence. Behrakis Chair in Pharmaceutical Biotechnology.